A28695B is a potent polyether antibiotic that was originally isolated from Streptomyces albus.

A274 is an extensively conjugated phenol that has recently shown to be present as a common trace constituent in randomly selected batches of commercial tissue culture media. It is a highly aromatic and mono-substituted phenol antioxidant produced during differentiation of neuroblastoma cells.

A-123189 is a novel, selective and potent α1D antagonists in both the α1 clonal cell lines and in in vitro tissue strips. It shares with BMY7378 and SNAP8719 the common structural features of a substituted phenylpiperazine and a heterocycle attached via a two-carbon linker. The 5-phenyl substitution on the heterocyclic attachment was shown to impart […]

A331440 is an inverse agonists/antagonists or modulator of the H3 receptor. Recent studies suggest that the brain histaminergic system and especially the H3 receptors are involved in the regulation of alcohol consumption and alcohol-induced behaviors. Part of this effect might be due to a modulation of ethanol-induced sedation by central histamine.

A 201A is an aminonucleoside antibiotic that is isolated from Streptomyces capreolus. A201A has a unique nucleoside structure with potent antibacterial activities. It is composed of 6-dimethylaminopurine, 3-amino-3-deoxyribose, p-hydroxy-alpha-methylcinnamic acid, a novel unsaturated hexofuranose and 3,4-di-O-methylrhamnose. A201A is inactivated by a phosphotransferase activity from Streptomyces capreolus NRRL 3817, the producing organism. Isolation and molecular characterization […]

A-317920, a piperazine amide, is an inverse agonist radioligand for the H3R receptor. A-317920 potently antagonize native H3Rs by blocking histamine inhibition of potassium-evoked [3H]histamine release from rat brain cortical synaptosomes (pKb values = 8.6 and 9.3) and (R)-alpha-MeHA reversal of electric field-stimulated guinea pig ileum contractions (pA2 values = 7.1 and 8.3). A-317920 is […]

Ruboxistaurin mesylate (LY333531 mesylate), the mesylate salt of Ruboxistaurin, is a potent and specific inhibitor of PKCβ (protein kinase C) with antidiabetic activity. It acts by competitively and reversibly inhibiting PKCβ1 and PKCβ2 with IC50 values of 4.7 and 5.9 nM respectively. It has the usefulness to treat diabetic nephropathy and diabetic macular edem. LY333531 […]

A28086B is an ionophore antibiotic structurally related to narasin, it was derived from fermentation and the structure was elucidated using electron impact and field desorption mass spectrometry. The ionic fragmentation of A28086B and its derivatives is discussed and compared with that of salinomycin, whose structure has been determined by X-ray diffraction.

A 1062 is an inhibitor of resolvase-binding. The mechanism of action for A1062 is to inhibit the resolvase binding to the res site.

A1-226 is a cephalosporin antibiotic that belongs to the class of β-lactam antibiotics, it was originally isolated from the fungus called ‘Acremonium’, previously known as ‘Cephalosporium’. It is a potassium salt that has the advantage of improved water solubility which is required for preparing a solution for IM injection.