A-130B is a novel and potent polyether antibiotic originally isolated from the metabolites of strepto,yces hygroscopicus by a Japanese research group in 1980.

A23887(A 23887 or A-23887) is a tetracyclic spiro amine which has previously been shown to have considerable affinity for dopamine D-2 receptors. It is important for defining the pharmacophore for D-2 antagonist activity due to its limited conformational freedom. This compound is important for defining the pharmacophore for D-2 antagonist activity due to their limited […]

A-286501 is a novel and potent carbocyclic nucleoside AK (Adenosine kinase) inhibitor with an IC50 of 0.47 nM and has analgesic and anti-inflammatory activities. It has no significant activity (IC50 >100 microM) at other sites of ADO (Adenosine) interaction (A1, A2A, A3 receptors, ADO transporter, and ADO deaminase) or other (IC50 value >10 microM) neurotransmitter […]

A 30312 is a new fused indoles that was found to overcome multidrug resistance in P388/Adr cells in vitro. It potentiated the cytotoxicity of the antitumor drugs such as Adriamycin, vinblastine, and vincristine in multidrug-resistant cells with no effect on drug-sensitive parent P388 cells. A 30312 significantly increased the ATP-dependent accumulation of [3H]-vinblastine and inhibited […]

A 1110U is a potent inactivator of ribonucleotide reductases of herpes simplex and varicella-zoster viruses and a potentiator of acyclovir. It has been shown to be synergistic with acyclovir to produce chemotherapeutic effects on herpes skin lesions.

A 21960 is able to inhibit the synapse formation between resolvase and two directly repeated res sites, and subsequently block the site-specific recombination reaction. The Tn3-encoded resolvase protein promotes a site-specific recombination reaction between two directly repeated copies of the recombination site res. A21960 does not affect resolvase binding and bending of the DNA but […]

Discovered by a Japanese group, A 17002 C is a new metabolite produced by Actinoplanes strains, structurally related to the virginiamycin factor M. On the basis of physico-chemical data, MS, IR, 1H and 13C NMR, structure I is assigned to A 17002 C.

Produced by an unidentified strain of Streptomyces species, A121 is a non-polyene antifungal antibiotic isolated and purified to homogeneity. As an antibiotic, A121 was found to be active against a number of filamentous fungi including some plant and human pathogens. On the basis of its infrared spectrum, proton magnetic resonance, mass spectra, and some chemical […]

A 22700 (also called A22700) is chemical with the name of 3,5-dichloro-N-cyclopropyl-4-(methylamino)benzamide, MW: 259.13; Molecular Formula: C11H12Cl2N2O

DORA-22 is a novel, potent and selective dual orexin receptor antagonist that may be useful for insomnia and AD-relevant symptoms. It can lower histamine levels in the lateral hypothalamus and prefrontal cortex without lowering hippocampal acetylcholine. DORA-22 suppresses the release of the wake neurotransmitter histamine in the lateral hypothalamus, prefrontal cortex, and hippocampus with no […]