A 20832 is a potent inhibitor that inhibits resolvase-promoted site-specific recombination postsynaptically at strand cleavage. It does not inhibit resolvase binding to res, as measured by filter binding, or synapse formation. Inhibition of resolvase-promoted site-specific recombination by A20832 occurs postsynaptically at strand cleavage. DNase I analysis in the presence of A20832 indicates that only site […]

Ulodesine (formerly also known as BCX4208) is a novel and potent inhibitor of purine nucleoside phosphorylase (PNP) with the potential to be used for the treatment of psoriasis and gout. It inhibits PNP with an IC50 of 0.5 nM. It is currently being developed by Biocryst as a once-daily oral, chronic treatment for gout. Ulodesine […]

A 25794 is an antibiotic that may have antidepressant activities. Chemical name: (2E)-N-(1,1-dimethylprop-2-yn-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-enamide; MW: 303.36; MF: C17H21NO4; Other name: A 25794; A-25794; A25794.

A110 is a novel, potent and selective inhibitor of IMPDHs. It binds to the NAD(+) cofactor site and forms a ternary complex with IMP. In combination with steady-state initial rate studies, the results show that the inhibitor A110 binds with high affinity (Kd ≈ 50 nM) predominantly to the covalent intermediate on the reaction pathway. […]

A-269A (also referred to as A269A) is a streptothricin-like antibiotic that was isolated from the culture broth of Streptomyces sp., strain No. A-269. The structure of the antibiotic was examined by 1H NMR, 13C NMR and fast atom bombardment mass spectra studies. Based on the spectroscopic data, A-269A was assumed to be a mixture of […]

A(2)C is a fatty acid-like derivative.

A 33853 (A33853; A-33853), a tetraacetyl that contains an anhydride moiety, is an antibiotic originally isolated from culture broth of Streptomyces sp. The synthetic analog of it was screened for the inhibition of L. donovani, T. b. rhodesiense, T. cruzi, and P. falciparum cultures followed by determination of IC(50) in L. donovani and cytotoxicity on […]

A 113 is a biochemical with the chemical name of D-Galactose,2-deoxy-2-[[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]amino]-,4-(dihydrogen phosphate) 3-[(3R)-3-[(1-oxotetradecyl)oxy]tetradecanoate] (9CI).

A-10749 (also known as A 10749; A-10749; A10749; NSC 30379) is a new chemical that has shown antidepressant activity.

PF-915275 (PF915275) is a novel and selective inhibitor of human 11β-hydroxysteroid dehydrogenase type 1 (11betaHSD1) with Ki of