Isotanshinone I is a novel and potent inhibitor of α-glucosidase

TM2-115, BIX-01294 derivative; inhibitor of malaria parasite histone methyltransferases

JBJ-09-063, allosteric inhibitor of mutant-EGFR

P163-0892, antifungal agent against Cryptococcus Species

Simmiparib HCl is a dual PARP1/2 inhibitor (IC50 = 1.75/0.22 nM) with anticancer activity. It selectively inhibits PARP1 with >90-fold higher potency than the other PARPs (PARP3, TNKS1, TNKS2).

AMP-PNP (Adenylyl-imidodiphosphate tetralithium), a non-hydrolysable analogue of ATP, is a novel Kir6 (KATP) channel blocker that inhibits fast axonal transport and stabilizes the interaction of membranous organelles with microtubules.

Adalimumab (trade name Humira; also known as Anti-Human TNF-alpha, Human Antibody) is a human monoclonal IgG1 antibody targeting tumour necrosis factor α (TNF-α). Adalimumab is a medication used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, ulcerative colitis, psoriasis, hidradenitis suppurativa, uveitis, and juvenile idiopathic arthritis. Use is generally only recommended in people who […]

Rituximab (trade name: Rituxan; Anti-Human CD20 type I, Chimeric Antibody) is an anti-CD20 chimeric monoclonal antibody (mAb) used to treat certain autoimmune diseases and types of cancer such as B-cell malignancies as well as organ transplantation. Rituximab is used for non-Hodgkin’s lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, granulomatosis with polyangiitis, idiopathic thrombocytopenic purpura, pemphigus vulgaris, […]

IRAK4-IN-16 is a novel and potent inhibitor of interleukin-1 receptor-associate kinase-4 (IRAK4)

Hetrombopag (SHR8735; Herombopag; Hengqu) is a novel, potent, orally bioavailable, and non-peptide thrombopoietin (TPO) receptor agonist developed by Jiangsu Hengrui Pharmaceutical for the treatment of thrombocytopenia and aplastic anaemia. In June 2021, hetrombopag gained the first approval in China as a second-line treatment for primary immune thrombocytopenia (ITP) and severe aplastic anaemia (SAA) in adults. […]