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Hetrombopag

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Hetrombopag
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Cat #: V20452 CAS #: 1257792-41-8 Purity ≥ 98%

Description: Hetrombopag (SHR8735; Herombopag; Hengqu) is a novel, potent, orally bioavailable, and non-peptide thrombopoietin (TPO) receptor agonist developed by Jiangsu Hengrui Pharmaceutical for the treatment of thrombocytopenia and aplastic anaemia. In June 2021, hetrombopag gained the first approval in China as a second-line treatment for primary immune thrombocytopenia (ITP) and severe aplastic anaemia (SAA) in adults. Hetrombopag can be used to treat low platelet levels in people who have a certain blood disorder called chronic immune thrombocytopenia purpura or who have chronic hepatitis C. It may also be used to treat people with a certain blood disorder.

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Molecular FormulaC25H24N4O5
CAS No.1257792-41-8
SMILES CodeO=C(C1=CC=C(C2=CC=CC(NNC3=C(C)NN(C4=CC=C5CCCCC5=C4)C3=O)=C2O)O1)O 
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.