(Rac)-LM11A-31 dihydrochloride is an isomer of LM11A-31 dihydrochloride. LM11A-31 dihydrochloride, a non-peptide p75NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist.

SCH00013 is a novel and potent Ca2+ sensitizer that elicits a moderate positive inotropic effect without significant alteration of Ca2+ transients. As a cardiotonic agent, SCH00013 primarily acts via an increase in myofibrillar Ca++ sensitivity, with a significant Ca(2+)sensitizing effect at pH 7.2 to 7.4. SCH00013 does not have a positive chronotropic effect and has […]

GNE-140 racemate is a novel and potent lactate dehydrogenase (LDHA) inhibitor which is a racemic mixture of (R)-GNE-140 and (S)-GNE-140. Metabolic reprogramming in tumors represents a potential therapeutic target. Herein we used shRNA depletion and a novel lactate dehydrogenase (LDHA) inhibitor, GNE-140, to probe the role of LDHA in tumor growth in vitro and in […]

EphB1-IN-10 is a novel, potent, selective and irreversible/covalent inhibitor of receptor tyrosine kinase EphB1.

GLL398 (GLL-398) is a novel, potent, orally bioavailable, and selective estrogen receptor downregulator. GLL-398 strongly binds to ERα in a fluorescence resonance energy transfer binding assay (IC50 =1.14 nM) and potently degrades ERα in MCF-7 breast cancer cells (IC50 = 0.21 μM). Most importantly, the introduction of the boronic acid group confers superior oral bioavailability […]

PF-184 is a novel and potent IKK-2 inhibitor

RIPK2-IN-2 is a novel and potent inhibitor of protein-2 (RIP2) kinase

Streptomycin is a novel and potent antibiotic

SD-1008, JAK2/3 inhibitor

mDPR(Boc)-Val-Cit-PAB is a novel and potent ADC linker