Metaxalone (also known as AHR438; NSC170959) is a skeletal muscle relaxant prescribed for the short-term treatment of painful muscle spasms caused by strains, sprains, and other musculoskeletal conditions. It is considered to be a moderately strong muscle relaxant, with relatively low incidence of side effects. Metaxalone appears to interact with the cytochrome p450 system and […]

Fluticasone furoate, a synthetic corticosteroid derived from fluticasone, is novel and potent corticosteroid used for the treatment of allergic rhinitis.

Uramustine (also known as Uracil mustard) is a novel, potent and orally bioactive DNA alkylating agent with antineoplastic activities, it is effective in the treatment of lymphosarcoma, chronic lymphatic leukaemia, and thrombocythemia.

LY-334370 HCl, the hydrochloride of LY-334370, is a novel, potent and selective 5-HT1F receptor agonist with Ki values of 1.6 nM. It displays antimigraine effects.

CCRP2(also known as TLX agonist 1 and SUN-23314) ,is a novel orphan nuclear receptor tailless (TLX, NR2E1) modulator (EC50=1μM; Kd= 650 nM). TLX agonist 1 potentiates TLX transcriptional repressive activity. CCRP2 was reported in PLoS One . 2014 Jun 17;9(6):e99440.

SKI-II HCl is a substrate competitive, reversible, and highly specific inhibitor of sphingosine kinase. Sphingosine kinases (Sphk) 1 and 2 play tumour-promoting roles in different cancer types including HCC and thus represent promising pharmacological targets. Co-administration of 5-FU and SKI-II at low sub-toxic concentrations of 20 μM and 5 μM, respectively, synergistically inhibit cell proliferation, […]

Dicyclohexylamine, an inhibitor of Spd synthesis, is a secondary amine with the chemical formula HN(C6H11)2. It is a colorless liquid, although commercial samples can appear yellow. It has a fishy odor, typical for amines. It is sparingly soluble in water.

(R)-Oxiracetam is the R-isomer of oxiracetam (also known as ISF 2522), which is a widely used nootropic drug and improves memory and learning in patients with cognitive impairments. Oxiracetam (50 mg/kg i.p.) improves avoidance acquisition in BALB/c mice. Oxiracetam (100 mg/kg i.p.) reduces the scopolamine-induced amnesic effect and decrease in acetylcholine level in the cortex […]

Guanfacine HCl, the hydrochloride salt of Guanfacine, is a potent, selective and centrally acting alpha-2 adrenergic agonist with antihypertensive activity and with Kd of 31 nM. It displays 60-fold selectivity over α2B-adrenoceptors. Alpha-2 receptor stimulation by guanfacine hydrochloride results in a decreased sympathetic outflow from the vasomotor center to the heart, kidneys, and peripheral vasculature. […]

Methoxyamine HCl is a novel, potent and orally bioavailable small molecule inhibitor with potential adjuvant activity. Methoxyamine covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis. This agent may potentiate the anti-tumor activity of alkylating agents. Check for […]