NVP-DKY709 (NVP-DKY-709; DKY-709) is a first-in-class selective cereblon (CRBN) glue degrader of IKZF2 with anticancer and may be used for cancer immunotherapy. It spares IKZF1 and IKZF3 from degradation. X-ray crystal structure of IKZF2 zinc fingers bound to DDB1:CRBN:NVP-DKY709 explained the target selectivity of NVP-DKY709. In vitro, NVP-DKY709 modulated Treg cell and Teff cell functions. […]

RR6 (RR-6; RR 6) is a novel, orally bioactive and selective vanin inhibitor. Oral administration of RR6 in rats completely inhibited plasma vanin activity and caused alterations of plasma lipid concentrations upon fasting, thereby illustrating its potential use in chemical biology research.

1R,3S-RSL 3 is a natural harmala alkaloid.

Ac-DEVD-AFC is a novel fluorogenic substrate with λex of 400 nm, and λem of 530 nm.

Dihydroisotanshinone I is a novel and potent bioactive chemical

(E/Z)-Demethoxycurcumin is a natural curcuminoid/Curcumin derivative isolated from curcuma species with anti-inflammatory, anti-coagulant and anti-proliferative activity. Reference: Studies on active substances in the herbs used for Oketsu (“stagnant blood”) in Chinese medicine. III. On the anticoagulative principles in curcumae rhizoma. CHEMICAL & PHARMACEUTICAL BULLETIN, 1985;33(4):1499–1502

(E/Z)-Methyl mycophenolate is the mixture of E and Z-configurational isomers of Methyl mycophenolate which is the methyl ester of mycophenolic acid and an impurity of Mycophenolate mofetil. Methyl mycophenolate is a prodrug of mycophenolic acid (MPA). It is a naturally occuring compound isolated from marine-derived fungus Phaeosphaeria spartinae and acts as an inhibitor of inosine […]

BCECF-AM, also called 2′,7′-Bis- (2-Carboxyethyl)-5- (and-6)-Carboxyfluorescein, Acetoxymethyl Ester, is a novel and potent fluorescent indicator which is cell membrane permeable and is thus widely used as a fluorescent marker/indicator for measurement of intracellular pH. It is the Acetoxymethyl Ester form of BCECF.

Isorhamnetin-3-O-glucoside is a natural product found in various vegetables and rice. After digestion, Isorhamnetin-3-O-glucoside can be metabolized in intestinal microbiota. Reference: Analysis of the Metabolites of Isorhamnetin 3-O-Glucoside Produced by Human Intestinal Flora in Vitro by Applying Ultraperformance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry. J Agric Food Chem. 201462122489-2495.

VAF347 (VAF-347) is a novel and potent aryl hydrocarbon receptor (AhR) agonist which is cell permeable and has highly affinity against aryl hydrocarbon receptor (AhR). It has anti-inflammatory effects by inducing AhR signaling and nhibiting the development of CD14+CD11b+ monocytes from granulo-monocytic (GM stage) precursors.