TH-237A (also known as meso-GS 164) is a novel and potent neuroprotective agent exhibiting favorable permeation across the blood brain barrier. TH-237A has neuroprotective properties against β-amyloid (Aβ)-induced neurodegeneration associated with Alzheimer’s disease. Exposure of neuronal cultures to Aβ peptide in the presence of 5 nM TH-237A resulted in a 50% increase in survival. Neuronal […]

Risedronate sodium (NE-58095) is a novel and potent pyridinyl biphosphonate which acts by inhibiting osteoclast-mediated bone resorption. Risedronate is prepared as its sodium salt risedronate sodium, is often used as a bisphosphonate used to strengthen bone, treat or prevent osteoporosis, and treat Paget’s disease of bone.

Tebanicline hydrochloride (also known as ABT-594, Ebanicline and ABT594 hydrochloride) is a novel, potent, orally bioavailable nAChR modulator with effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM. Tebanicline is a potent synthetic nicotinic (non-opioid) analgesic drug developed by Abbott as a less toxic analogue […]

Neridronate (also known as Neridronic acid) is an aminobisphosphonate used in Italy for the treatment of osteogenesis imperfecta (OI) and Paget’s disease of bone (PDB). Neridronate is effective also in other skeletal diseases such as osteoporosis, algodystrophy, hypercalcemia of malignancy, and bone metastases. Neridronic acid, also known neridronate, is a bisphosphonate. Neridronic acid treatment has […]

Tebanicline tosylate (also known as ABT-594 tosylate, Ebanicline tosylate and ABT594 tosylate) is a novel, potent, orally bioavailable nAChR modulator with effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM. Tebanicline is a potent synthetic nicotinic (non-opioid) analgesic drug developed by Abbott as a less […]

Levomefolate calcium (LMCA and BAY 86-7660), the calcium salt of 5-methyltetrahydrofolic acid, is an artificial form of folate and a biologically active form of folic acid that functions, in conjunction with Vitamin B12 , as a methyl-group donor involved in the conversion of homocysteine to methionine. Levomefolate is included in formulations of certain oral contraceptives […]

H3B-8800 is a novel, potent and orally bioavailable modulator of the SF3b complex. H3B-8800 potently and preferentially kills spliceosome-mutant epithelial and hematologic tumor cells. These killing effects of H3B-8800 are due to its direct interaction with the SF3b complex, as evidenced by loss of H3B-8800 activity in drug-resistant cells bearing mutations in genes encoding SF3b […]

ITE is a novel and potent agonist of aryl hydrocarbon receptor (AhR) with immunosuppressive activity. It activates AHR with a Ki of 3 nM.

Isopropamide iodide (5579MD; 5579-MD) is a quaternary ammonium-based and long-acting anticholinergic agent used in the treatment of peptic ulcers and other gastrointestinal disorders involving hyperacidity (gastrointestinal acidosis) and hypermotility. It is most often provided as an iodide salt, but is also available as a bromide or chloride salt.

TS-011 (TS 011; TS011) is a novel and potent inhibitor of 20-Hydroxyeicosatetraenoic acid synthesis. It can improve cerebral microcirculatory autoregulation impaired by middle cerebral artery occlusion in mice.