CCR2 antagonist 4 (Teijin compound 1) is a novel and potent CCR2 antagonist (IC50 = 180 nM for CCR2b) with anti-inflammatory and immunomodulatory effects.

Etanercept (Enbrel) is a novel and potent tumor necrosis factor (TNF) inhibitor with anti-inflammatory and immunmodulatory effects. It has been approved for use in adults to prevent joint damage caused by rheumatoid arthritis/RA, psoriatic arthritis, and/or ankylosing spondylitis. It is a dimeric fusion protein that act as a TNF blocker/inhibitor by competitively blocking/inhibiting the binding […]

Mildronate dihydrate is a novel and potent cardioprotective drug

SR-318 (SR318) is a novel and potent p38 MAPK inhibitor with anti-cancer and anti-inflammatory activity. It inhibits p38α and p38β with IC50s of 5 and 32 nM, respectively. SR 318 also inhibits LPS-induced TNF-α release in isolated human whole blood (IC50 = 0.283 µM).

Democonazole is an antifungal drug and antimycotic agent.

Disitertide is a novel and potent inhibitor of TGF-β1

3X FLAG Peptide is a novel and potent peptide.

DMT1 blocker 1 is a novel and potent blocker of divalent metal transporter 1 (DMT1) with potential use as iron overload therapeutics. It inhibits metal transporter 1 with IC50 of 0.64 μM Reference: Cadieux JA, et al. Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1). Bioorg Med Chem […]

Stearoylcarnitine is a novel and potent fatty ester lipid molecule

J-113863 (J113863) is a novel and potent CCR1 (CD18) antagonist with anti-inflammatory. It inhibits CCR1 with with IC50 of 0.9 nM and 5.8 nM for human and mouse CCR1 receptors, respectively.