Polyoxyl 15 hydroxystearate (Solutol HS 15; poly-oxyethylene esters of 12-hydroxystearic acid) is a novel non-ionic surfactant and emulsifier used as a solubilizer in formulation of compounds with low water solubility. Essentially, it is used to enhance the water/aqueous solubility of Class 2 and 4 [Biopharmaceutical Classification System (BCS)] lipophilic molecules. It can also increase the […]

Melperone (Bunil; FG-5111) is a potent and butyrophenone-based antipsychotic drug and a neuroleptic, acting as an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine. It can be used for sleep induction which is frequently prescribed in psychiatric setting. It has also been used for a variety of other indications, including the treatment of schizophrenia, but […]

Atorvastatin acetonide tert-butyl ester is an intermediate during the synthesis of HMG-CoA reductase inhibitor Atorvastatin.

CAS1333608-16-4 is a biochemical compound

ABI-274 is a novel, orally bioavailable, highly potent and selective tubulin/mitotic inhibitor (specifically a microtubule destabilizer) targeting the colchicine binding site, belonging to the so called colchicine binding site inhibitor (CBSI). It has shown potent anticancer activities in vitro and in vivo, as well as favorable pharkacokinetics such as good oral bioavailability.

5(6)-FITC (Fluorescein isothiocyanate) is an amine-reactive derivative of fluorescein dye with a wide-range of applications in fluorescence microscopy, flow cytometry and immunofluorescence-based assays such as Western blotting and ELISA, as a label for antibodies and other probes.

CCR2 antagonist 4 HCl (Teijin compound 1 hydrochloride) is a novel and potent CCR2 antagonist (IC50=180 nM for CCR2b) with anti-inflammatory and immunomodulatory effects.

Acetylspiramycin (Spiramycin II; Spiramycin B; Foromacidin B), an acetylated analog of Spiramycin, is an orally bioactive macrolide antibiotic found in various Streptomyces species. It has antimicrobial activity against gram-positive organisms such as Streptococcus pyogenes, S. viridans, Corynebacterium diphtheriae and methicillin-sensitive Staphylococcus aureus. Acetylspiramycin also exhibits antiprotozoal activity against parasitic infections caused by Cryptosporidium spp.

SAR405 R enantiomer is the less active R-isomer of SAR-405, which is a PIK3C3/Vps34 inhibitor.

β-Anhydroicaritin is a naturally occurring bioactive compound isolated from Boswellia carterii Birdware with various biological activity such as antiosteoporosis, estrogen regulation and antitumor effects. It can decrease the production of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice.