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ABI-274

This product is for research use only, not for human use. We do not sell to patients.

ABI-274
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5mg$5003-6 Days
10mg$8503-6 Days
25mg$16003-6 Days
50mg$28003-6 Days
email: [email protected]        [email protected]

Cat #: V41098 CAS #: 1253697-93-6 Purity ≥ 99%

Description: ABI-274 is a novel, orally bioavailable, highly potent and selective tubulin/mitotic inhibitor (specifically a microtubule destabilizer) targeting the colchicine binding site, belonging to the so called colchicine binding site inhibitor (CBSI). It has shown potent anticancer activities in vitro and in vivo, as well as favorable pharkacokinetics such as good oral bioavailability.

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Molecular FormulaC20H20N2O4
CAS No.1253697-93-6
SMILES CodeO=C(C1=CNC(C2=CC=C(C)C=C2)=N1)C3=CC(OC)=C(OC)C(OC)=C3 <br/>
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.