DMT1 blocker 1

This product is for research use only, not for human use. We do not sell to patients.

DMT1 blocker 1
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5mg$3253-6 Days
10mg$5503-6 Days
25mg$9503-6 Days
50mg$15503-6 Days
100mg$23503-6 Days

Cat #: V33125 CAS #: 1354790-56-9 Purity ≥ 99%

Description: DMT1 blocker 1 is a novel and potent blocker of divalent metal transporter 1 (DMT1) with potential use as iron overload therapeutics. It inhibits metal transporter 1 with IC50 of 0.64 μM Reference: Cadieux JA, et al. Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1). Bioorg Med Chem Lett. 2012 Jan 1;22(1):90-5.

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Molecular Weight (MW)294.31
Molecular FormulaC₁₆H₁₄N₄O₂
CAS No.1354790-56-9
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.3978 mL16.9889 mL33.9778 mL67.9556 mL
5mM0.6796 mL3.3978 mL6.7956 mL13.5911 mL
10mM0.3398 mL1.6989 mL3.3978 mL6.7956 mL
20mM0.1699 mL0.8494 mL1.6989 mL3.3978 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.