MK-8666 tromethamine is a novel and potent agonist of g-protein coupled receptor 40 (gpr40)

Atromentin is a novel and potent natural chemical compound

Rabeximod (ROB803; ROB-803) is a novel and potent immunomodulator for the treatment of moderate or severe active rheumatoid arthritis. It is currently undergoing phase II clinical trials. It reduced the arthritis by preventing the TLR2 and TLR4 mediated inflammatory cells activation.

Acid-PEG4-mono-methyl ester is a novel and potent PEG-linker

Cyclocytidine sulfate is a novel and potent anticancer agent

Benfosformin is a novel and potent bioactive compound

Amitriptylinoxide is a novel and potent antidepressant agent

AMG-126737 is a novel and potent inhibitor of human lung mast cell tryptase with greater than 10- to 200-fold selectivity versus other serine proteases. AMG-126737 has potential therapeutic utility in pulmonary disorders.

JNJ-55511118 is a novel, high affinity and selective negative modulator of AMPA receptors containing TARP-γ8 (Ki = 26 nM). JNJ-55511118 had excellent pharmacokinetic properties and achieved high receptor occupancy following orally bioavailable administration. JNJ-55511118 showed strong, dose-dependent inhibition of neurotransmission within the hippocampus, and a strong anticonvulsant effect.

Selatinib is a novel and potent dual EGFR/HER-2 inhibitor