AMG-126737 | CAS 224054-76-6

AMG-126737

This product is for research use only, not for human use. We do not sell to patients.

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Cat #: V5345 CAS #: 224054-76-6 Purity ≥ 98%

Description: AMG-126737 is a novel and potent inhibitor of human lung mast cell tryptase with greater than 10- to 200-fold selectivity versus other serine proteases. AMG-126737 has potential therapeutic utility in pulmonary disorders.

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Physicochemical and Storage Information
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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	678.82
Molecular Formula	C33H38N6O6S2
CAS No.	224054-76-6
Synonyms	AMG-126737; AMG 126737; AMG126737; 105RSZ5CNS; SCHEMBL7986111; AMG 126737; UNII-105RSZ5CNS

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.4731 mL	7.3657 mL	14.7314 mL	29.4629 mL
5mM	0.2946 mL	1.4731 mL	2.9463 mL	5.8926 mL
10mM	0.1473 mL	0.7366 mL	1.4731 mL	2.9463 mL
20mM	0.0737 mL	0.3683 mL	0.7366 mL	1.4731 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.