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JNJ-55511118

This product is for research use only, not for human use. We do not sell to patients.

JNJ-55511118
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Cat #: V5402 CAS #: 2036081-86-2 Purity ≥ 98%

Description: JNJ-55511118 is a novel, high affinity and selective negative modulator of AMPA receptors containing TARP-γ8 (Ki = 26 nM). JNJ-55511118 had excellent pharmacokinetic properties and achieved high receptor occupancy following orally bioavailable administration. JNJ-55511118 showed strong, dose-dependent inhibition of neurotransmission within the hippocampus, and a strong anticonvulsant effect.

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Molecular Weight (MW)328.68
Molecular FormulaC14H8ClF3N2O2
CAS No.2036081-86-2
SynonymsJNJ-55511118; JNJ 55511118; JNJ55511118
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.0425 mL15.2124 mL30.4247 mL60.8495 mL
5mM0.6085 mL3.0425 mL6.0849 mL12.1699 mL
10mM0.3042 mL1.5212 mL3.0425 mL6.0849 mL
20mM0.1521 mL0.7606 mL1.5212 mL3.0425 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.