CB-6644 is a novel, potent, and selective inhibitor of RUVBL1/2 complex with anticancer activity, blocking the ATPase activity of RUVBL1/2 with an IC50 of 15 nM.

L-Kynurenine is a key intermediate and metabolite during the breakdown of amino acid L-tryptophan and the biosynthesis of nicotinamide adenine dinucleotide (NAD+) via the kynurenine pathway. It acts as an AHR/aryl hydrocarbon receptor agonist and is involved in a variety of neurological processes and diseases. L-Kynurenine is also a substrate for multple enzymes such as […]

BYK191023 Dihydrochloride (BYK-191023) is a novel, L-arginine competitive and selective inhibitor of inducible nitric oxide synthase (iNOS) with IC 50 values of 0.086, 17, and 162 μM for human recombinant iNOS, nNOS, and eNOS, respectively.

(+/-)-Roscovitine is a racemate. The R-isomer is Seliciclib (Roscovitine, CYC202) which is a novel, potent, selective and orally bioavailable small-molecule CDK inhibitor with IC50 of 0.65 μM, 0.7 μM and 0.16 μM for Cdc2, CDK2 and CDK5 in cell-free assays.

Tetrasul (V-101; V101; diphenylsulphide) is a potent pesticide used against spider mites and aphids.

CFLZ-567 (CFLZ567; CFLZ 567) is a key intermediate for the production of carfilzomib (Kyprolis) which is an irreversible proteasome inhibitor and approved anticancer drug.

PZ-128 (PZ128; P1pal-7) is a novel and potent PAR1 (protease-activated receptor-1) antagonist with antiplatelet, anti-metastatic, anti-angiogenic and anticancer activity and has the potential for the treatment of thrombosis. As a cell-penetrating lipopeptide pepducin, PZ-128 targets the cytoplasmic surface of PAR1 and interrupts signaling to internally-located G (PAR1-G) proteins.

Dexamethasone 9,11-epoxide, an epoxide compound found in patent CN 106520896 A and RU 2532902 C1, is an intermediate in the preparation of dexamethasone.

Nifenazone (Nicodon, Nicodone, Nicofesone) is a pyrazole-based anti-inflammatory drug used for treating a wide range of rheumatic conditions, also used as an analgesic.