Perampanel is discontinued (DEA controlled substance). Perampanel is a selective noncompetitive antagonist of AMPA receptors, the major subtype of ionotropic glutamate receptors. Perampanel was found to be effective in the treatment of refractory partial-onset seizures in clinical trials.

Nemorexant (Daridorexant; ACT-541468; Quviviq; ACT541468) is a novel and potent orexin receptors antagonist that has been approved in January 2022 for the treatment of Insomnia Disorder in Adult Patients. It inhibits Ox1 receptor and Ox2 receptors with IC50s of 2 nM and 3 nM, respectively. By specific binding to both orexin receptors, daridorexant inhibits the […]

Metoprolol HCl (Metomerck; Metop; Toprol; Lanoc; Selopral; Ritmolol; Lopressor), the hydrochloride salt of Metoprolol, is a potent β1 adrenergic receptor blocker approved as an anti-hypertensive drug for the treatment of high blood pressure and chest pain.

Psoralidin is a novel and potent anti-inflammatory agent, immunomodulatory agent.

Saxagliptin HCl (also known as BMS-477118; brand name: Onglyza) is a potent, orally bioactive, selective and reversible DPP4 (dipeptidyl peptidase-4) inhibitor with IC50 of 26 nM. Saxagliptin was approved in 2008 by FDA for the treatment of type 2 diabetes. Saxagliptin is a competitive DPP4 inhibitor that slows the inactivation of the incretin hormones, thereby […]

Gonadorelin is a novel and potent decapeptide

Senexin B is a novel, potent, orally bioavailable and selective CDK8/19 inhibitor. Senexin B inhibits CDK8/19 in low nanomolar range in vitro and in vivo as an ATP pocket binder, with very high target selectivity as indicated by kinome profiling. It is highly water-soluble, bioavailable, and produces no limiting toxicity upon prolonged administration in mice, […]

Acetylcholine bromide (ACH Bromide) is a biochemical compound that has nociceptive action.

AVN-101 HCl (AVN101; AVN 101), the hydrochloride salt of AVN-101, is a novel and potent 5-HT7 receptor antagonist with the potential to be used for the treatment of CNS disorders.

Rosarin is a naturally occurring cinnamyl alcohol glycoside found in Rhodiola rosea. It exhibits anti-inflammatory and neuroprotective activity by suppressing the expression of the proinflammatory factors such as iNOS, IL-1 β, and TNF-α.