MK-7622 is a novel, potent and highly selective positive allosteric modulator of the M1 muscarinic receptor that has entered Phase II studies in patients with Alzheimer’s disease.
Harmaline is a naturally occuring, beta-carboline/fluorescent indole alkaloid extracted from seeds of PEGANUM.
Solifenacin (YM-905; Vesikur; Vesicare) is a novel and potent muscarinic receptor antagonist that has been approved for the treatment of overactive bladder.
Mepenzolate Bromide is a muscarinic antagonist (Kis = 0.68 and 2.6 nM for human M2 and M3 receptors, respectively) used to treat gastrointestinal disorders.
Racanisodamine is a novel and potent muscarinic antagonist.
DREADD agonist 21 is a muscarinic hM3Dq DREADD receptor agonist.
Scopolamine HCl (Hyoscine), the hydrochloride salt of Scopolamine, is a drug approved for the treatment of motion sickness and postoperative nausea and vomiting.
Pirmenol HCl (Cl-845) is a potent antiarrhythmic agent that inhibits muscarinic acetylcholine receptor-operated K+ current in the guinea pig heart.
Norclozapine (ACP-104; NDMC; ACP104; N-Desmethylclozapine) is a major active metabolite of the atypical antipsychotic drug clozapine.
Nor-benzetimide (Norbenzetimide) is a major metabolite of benzetimide found in urine.