Scopolamine HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $545 | Check With Us |
| 5g | $830 | Check With Us |
| 10g | $1225 | Check With Us |
: Cat #: V14557 CAS #: 55-16-3 Purity ≥ 99%
Description: Scopolamine HCl (Hyoscine), the hydrochloride salt of Scopolamine, is a drug approved for the treatment of motion sickness and postoperative nausea and vomiting.
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| Molecular Weight (MW) | 339.81 |
|---|---|
| Molecular Formula | C17H22ClNO4 |
| CAS No. | 55-16-3 |
| Protocol | In Vitro | Scopolamine blocks nicotinic acetylcholine receptors (IC50=928 μM) and increases the expression of α7 nACh receptors. Scopolamine displays concentration-dependent competition with 0.6 nM [3H]Granisetron, yielding an average pKi of 5.17±0.24 (Ki=6.76 μM). Concentration-dependent competition of fluorescently labeled form of granisetron (G-FL) with Scopolamine gives an average pKi of 5.31±0.09 (Ki=4.90 μM).Scopolamine blocks muscarinic receptors and induces a cognitive deficit |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9428 mL | 14.7141 mL | 29.4282 mL | 58.8564 mL |
| 5mM | 0.5886 mL | 2.9428 mL | 5.8856 mL | 11.7713 mL |
| 10mM | 0.2943 mL | 1.4714 mL | 2.9428 mL | 5.8856 mL |
| 20mM | 0.1471 mL | 0.7357 mL | 1.4714 mL | 2.9428 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.