Loreclezole (R-72063; R 72063; R72063), a triazole analog, is a sedative, anti-seizure/anticonvulsant and antiepileptic agent that acts as a positive allosteric modulator (PAM) of GABAA receptor.

LAU159 is a novel, potent and functionally selective positive modulator of α1β3 GABA(A) receptor with an EC50 of 2.2 μM.

Etifoxine (HOE 36801) and etafenoxine, is a non-benzodiazepine GABAergic anxiolytic and anticonvulsant drug developed by Hoechst in the 1960s, and sold in approximately 40 countries for anxiety disorders, without the sedation and ataxia associated with benzodiazepine drugs.

Picrotoxin (cocculin) is a naturally occuring and poisonous crystalline plant compound.

Norepinephrine bitartrate (Levarterenol; L-Noradrenaline) is a potent and β1-selective adrenergic receptor agonist with EC50 of 5.37 μM.

Baclofen (also known as STX 209) is a derivative of gamma-aminobutyric acid and a selective GABAB receptor agonist.primarily used to treat spasticity. Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing It acts at spinal and supraspinal sites, reducing excitatory transmission. GABAB receptors are […]

U-93631 is a GABAA receptor antagonist. U-93631 causes rapid decay of gamma-aminobutyric acid-induced chloride currents in recombinant rat gamma-aminobutyric acid type A receptors.

Amentoflavone is a novel and potent inhibitor of CYP3A4 and CYP2C9.

Allopregnanolone [5α-pregnan-3α-ol-20-one or 3α,5α-tetrahydroprogesterone (3α,5α-THP), or SAGE-547, Brexanolone, zulresso and Allotetrahydroprogesterone] is a progesterone metabolite that serves as an allosteric modulator of the GABA (γ-aminobutyric acid) receptor.

Oxiracetam (also known as ISF 2522), a novel cyclic derivative of gamma-aminobutyric acid (GABA) which acts as a positive allosteric modulator of the AMPA receptors, is widely used as a nootropic drug to improve memory and learning in patients with cognitive impairments.