LAU159

This product is for research use only, not for human use. We do not sell to patients.

LAU159
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1200Check With Us
250mg$1800Check With Us
500mg$2700Check With Us

Cat #: V31861 CAS #: 2055050-87-6 Purity ≥ 99%

Description: LAU159 is a novel, potent and functionally selective positive modulator of α1β3 GABA(A) receptor with an EC50 of 2.2 μM.

References: Varagic Z, et al. Identification of novel positive allosteric modulators and null modulators at the GABAA receptor α+β- interface. Br J Pharmacol. 2013 May;169(2):371-83.

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Product Promise

Promise
Molecular Weight (MW)325.75
Molecular FormulaC₁₇H₁₂ClN₃O₂
CAS No.2055050-87-6
SMILES CodeO=C1N(C2=CC=CC(OC)=C2)N=C3C1=CNC4=C3C=C(Cl)C=C4.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.0698 mL15.3492 mL30.6984 mL61.3968 mL
5mM0.6140 mL3.0698 mL6.1397 mL12.2794 mL
10mM0.3070 mL1.5349 mL3.0698 mL6.1397 mL
20mM0.1535 mL0.7675 mL1.5349 mL3.0698 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.