Allopregnanolone

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$450	Check With Us
500mg	$690	Check With Us
1g	$1035	Check With Us

: [email protected] [email protected]

Cat #: V2878 CAS #: 516-54-1 Purity ≥ 98%

Description: Allopregnanolone [5α-pregnan-3α-ol-20-one or 3α,5α-tetrahydroprogesterone (3α,5α-THP), or SAGE-547, Brexanolone, zulresso and Allotetrahydroprogesterone] is a progesterone metabolite that serves as an allosteric modulator of the GABA (γ-aminobutyric acid) receptor.

References: J Neurosci. 2005 May 11;25(19):4706-18; PLoS One. 2015 Jun 3;10(6):e0128313; Neuroscience. 2013 Jul 23;243:64-75.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	318.49
Molecular Formula	C21H34O2
CAS No.	516-54-1
Storage	-20℃ for 3 years in powder formrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 10 mMrr
	Water: <1 mg/mLrr
	Ethanol: <1 mg/mL
SMILES Code	CC([C@H]1CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O
Synonyms	5α-pregnan-3α-ol-20-one or 3α,5α-tetrahydroprogesterone (3α,5α-THP), or SAGE-547, Brexanolone, and Allotetrahydroprogesterone; SAGE-547; SGE102; SAGE547; SGE-102; SAGE 547; SGE 102; zulresso

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.1398 mL	15.6991 mL	31.3982 mL	62.7963 mL
5mM	0.6280 mL	3.1398 mL	6.2796 mL	12.5593 mL
10mM	0.3140 mL	1.5699 mL	3.1398 mL	6.2796 mL
20mM	0.1570 mL	0.7850 mL	1.5699 mL	3.1398 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.