Golgicide A (GCA), a quinoline compound, is a cell-permeable, potent and rapidly reversible inhibitor of GBF1, which is one of the guanine nucleotide exchange factors (ArfGEFs). It is also an inhibitor of shiga toxin cytotoxicity. Golgicide A inhibits the effect of shiga toxin on protein synthesis with an IC50 of 3.3 μM in Vero cells. […]

Pocapavir, formerly known as SCH-48973 and V-073, is a novel, potent, and selective antienterovirus agent that is under clinical investigation to treat neonatal enterovirus sepsis. Pocapavir acts as a capsid inhibitor by preventing virion uncoating upon entry into the cell. The patient was treated with the novel antiviral, pocapavir, in addition to a standard heart […]

5-Hydroxy-6,7-dimethoxylflavone is natural product of the flavonoid class.

Pirodavir (formerly known as R 77975) is the prototype of a novel class of broad-spectrum antipicornavirus compounds. It is a capsid-binding antipicornavirus agent with potent in vitro activity against both group A and group B rhinovirus serotypes. Although its predecessor, R 61837, a substituted phenyl-pyridazinamine, was effective in inhibiting 80% of 100 serotypes tested (EC80) […]

Norwogonin is natural product of the flavonoid class.

Pleconaril (also known as VP 63843; Win 63843) is a capsid inhibitor and an antiviral drug that has the potential for the treatment of enterovirus infection and asthma. Pleconaril is effective in inhibiting replication with an IC50 of 50 nM. Pleconaril, administered either orally or intranasally, is active against viruses in the Picornaviridae family, including […]