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| Size | Price | Stock |
|---|---|---|
| 250mg | $1080 | Check With Us |
| 500mg | $1650 | Check With Us |
| 1g | $2475 | Check With Us |
: Cat #: V2892 CAS #: 146949-21-5 Purity ≥ 98%
Description: Pocapavir, formerly known as SCH-48973 and V-073, is a novel, potent, and selective antienterovirus agent that is under clinical investigation to treat neonatal enterovirus sepsis. Pocapavir acts as a capsid inhibitor by preventing virion uncoating upon entry into the cell. The patient was treated with the novel antiviral, pocapavir, in addition to a standard heart failure regimen. The dystrophic calcification persisted but the left ventricle remodeled significantly. This is the first reported use of pocapavir for this indication. Treatment with pocapavir was safe and significantly accelerated virus clearance. Emergence of resistant virus and transmission of virus were seen in the context of a clinical isolation facility.
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| Molecular Weight (MW) | 423.72 |
|---|---|
| Molecular Formula | C21H17Cl3O3 |
| CAS No. | 146949-21-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mM in DMSOr |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| SMILES Code | ClC1=C(OCC2=CC=C(COC3=CC=C(OC)C=C3Cl)C=C2)C(Cl)=CC=C1 |
| Synonyms | Pocapavir; SCH-48973; SCH 48973; SCH48973; V-073; V 073; V073; |
| Protocol | In Vitro | In vitro activity: Pocapavir, formerly known as SCH-48973 and V-073, is a novel, potent, and selective antienterovirus agent that is under clinical investigation. Pocapavir acts as a capsid inhibitor by preventing virion uncoating upon entry into the cell. The patient was treated with the novel antiviral, pocapavir, in addition to a standard heart failure regimen. The dystrophic calcification persisted but the left ventricle remodeled significantly. This is the first reported use of pocapavir for this indication. Treatment with pocapavir was safe and significantly accelerated virus clearance. Emergence of resistant virus and transmission of virus were seen in the context of a clinical isolation facility. Kinase Assay: Pocapavir belongs to a picornavirus antiviral mechanistic class called capsid inhibitors that block virus uncoating and viral RNA release into cells, which in turn prevents virus replication Cell Assay: Pocapavir acts as a capsid inhibitor, preventing virion uncoating upon entry into the cell. Treatment with Pocapavir is safe and significantly accelerates virus clearance |
|---|---|---|
| In Vivo | Pocapavir acts as a capsid inhibitor, preventing virion uncoating upon entry into the cell. Treatment with Pocapavir is safe and significantly accelerates virus clearance |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3600 mL | 11.8002 mL | 23.6005 mL | 47.2010 mL |
| 5mM | 0.4720 mL | 2.3600 mL | 4.7201 mL | 9.4402 mL |
| 10mM | 0.2360 mL | 1.1800 mL | 2.3600 mL | 4.7201 mL |
| 20mM | 0.1180 mL | 0.5900 mL | 1.1800 mL | 2.3600 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.