Trifluridine (also known as trifluorothymidine; FTD; NSC-529182; NSC-75520; NSC529182; NSC75520; Viroptic), an inhibitor of the thymidylate synthase and DNA synthesis, is an approved anti-herpesvirus antiviral agent/medications used mainly for treating infections in the eye.

Sofosbuvir (also known as PSI-7977, GS-7977; PSI7977; GS7977; Vosevi; Hepcinat; Hepcvir; Resof; Sovaldi and Virunon), a blockbuster anti-HCV drug, is an HCV NS5B polymerase inhibitor that has been approved for the treatment of chronic hepatitis C virus (HCV) infections.

Rifaximin (BRN-3584528; L-105SV; Fatroximin; Normix; Rifacol; Rifaxidin; Rifaxin; Ritacol; Rifaximin; RCIFAX, Rifagut, Xifaxan, Zaxine) is an orally bioavailable and semi-synthetic RNA synthesis inhibitor used to treat traveler’s diarrhea caused by certain bacteria.

Fludarabine (also known as FaraA, Fludarabinum; NSC-118218; F-ara-A, HSDB6964; NSC118218; HSDB-6964) is a potent STAT1 activation inhibitor and a DNA synthesis inhibitor that has been approved as a chemotherapeutic drug for the treatment of leukemia and lymphoma.

Mercaptopurine (also called 6-MP; 6-Thiohypoxanthine; 6-thiopurine; 6-mercaptopurine; Purinethol) is an approved anticancer medication used to treat malignancies.

B02 (also called RAD51-IN-02)is a potent and specific inhibitor of human RAD51 with an IC50 of 27.4 μM.

Raltitrexed (formerly Thaltitrexed; ICID1694; TDX, ZD-1694; D1694; ICI-D1694; trade name: Tomudex), a quinazoline folate analog, is an approved antimetabolite anticancer drug used in cancer chemotherapy for treating colorectal cancer and malignant mesothelioma.

Triapine (formerly NSC-663249; AIDS-179996; AP; OCX191; PAN-811; OCX-191; 3AP; NSC663249; PAN811; 3-AP; PAN 811) is a so-called ribonucleotide reductase inhibitor being investigated for cancer treatment.

PFM01 is a nuclease-specific MRE11 inhibitor.

D-I03 (DI03) is a novel and potent RAD52 inhibitor (Kd = 25.8 µM) with anticancer activity.