D-I03
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $550 | To Be Confirmed |
| 100mg | $900 | To Be Confirmed |
| 200mg | $1350 | To Be Confirmed |
: Cat #: V40642 CAS #: 688342-78-1 Purity ≥ 99%
Description: D-I03 (DI03) is a novel and potent RAD52 inhibitor (Kd = 25.8 µM) with anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 428.64 |
|---|---|
| Molecular Formula | C23H36N6S |
| CAS No. | 688342-78-1 |
| Protocol | In Vivo | D-I03 (50 mg/kg/day; intraperitoneal injection; daily; for 7 days; nu/nu mice) treatment reduces BRCA1-deficient MDA-MB-436 tumor growth. Talazoparib puls D-I03 does not affect the growth of BRCA1-proficient tumors and does not exert any significant toxicity against normal tissues and organs |
|---|---|---|
| Animal model | Nu/nu mice injected with BRCA1-deficient MDA-MB-436 cells | |
| Dosages | 50 mg/kg/day | |
| Administration | Intraperitoneal injection; daily; for 7 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3330 mL | 11.6648 mL | 23.3296 mL | 46.6592 mL |
| 5mM | 0.4666 mL | 2.3330 mL | 4.6659 mL | 9.3318 mL |
| 10mM | 0.2333 mL | 1.1665 mL | 2.3330 mL | 4.6659 mL |
| 20mM | 0.1166 mL | 0.5832 mL | 1.1665 mL | 2.3330 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.