Rifampin (Rimactane; Arficin; Arzide; Rifampicin; Rifadin; Rimactane; Rimactan; Tubocin; Archidyn; Benemicin; Doloresum; Eremfat; Fenampicin; Sinerdol), an approved broad spectrum and semisynthetic antibiotic found in Streptomyces mediterranei, is mainly used to treat various bacterial infections such as TB-tuberculosis, leprosy, mycobacterium avium complex, and Legionnaires’ disease.
Folic acid (also known as Vitamin M; Vitamin B9; folate) is a one of the B vitamins and is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.
Isopimpinellin is natural product of the coumarin class.
Adenine sulfate (6-Aminopurine hemisulfate; Vitamin B4 hemisulfate), the sulfate salt form of adenine, is a purine derivative and a nucleobase with important biological functions.
Cidofovir (also known as HPMPC; GS-0504; HPMPC; (S)-HPMPC; Vistide) is a potent and injectable antiviral medication approved for the treatment of cytomegalovirus (CMV) retinitis with IC50 of 0.94 μM.
Cisplatin (CDDP; cis-Diaminodichloroplatinum; Trade names: Platinol; PlatinolAQ among others), an inorganic platinum complex acting as a DNA intercalating agent, is a widely used and classic chemotherapeutic drug and a potent inducer of growth arrest and apoptosis in a variety of cell types.
Bendamustine HCl (formerly also called SDX-105; EP-3101; Cytostasane; DD6304600; Treanda), the hydrochloride salt of bendamustine which is a bifunctional mechlorethamine derivative, is a potent DNA-alkylating/ cross-linking / damaging agent (IC50 = 50 μM in cell-free assay) approved for cancer treatment.
Clofarabine(formerly C1 F-Ara-A; C1 F-Ara-A; CAFdA; trade names: Clofarex; Clolar) is an antimetabolite anticancer chemotherapeutic drug and a purine nucleoside approved for the treatment of relapsed or refractory acute lymphoblastic leukemia.
Cycloheximide, produced by S. griseus, is a glutarimide antibiotic and an inhibitor of protein synthesis in eukaryotes (but not prokaryotes) with IC50 of 5-50 μM (IC50s of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively).
Fludarabine phosphate (formerly F-ara-A; Fludara; Beneflur; 2FaraAMP; NSC312887; NSC-312887), the phosphate salt of Fludarabine, is an adenosine analog and potent STAT-1 activation inhibitor with potential antineoplastic activity.