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Fludarabine (NSC 118218)

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Fludarabine (NSC 118218)
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1g$645Check With Us
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5g$1470Check With Us
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Cat #: V1379 CAS #: 21679-14-1 Purity ≥ 98%

Description: Fludarabine (also known as FaraA, Fludarabinum; NSC-118218; F-ara-A, HSDB6964; NSC118218; HSDB-6964) is a potent STAT1 activation inhibitor and a DNA synthesis inhibitor that has been approved as a chemotherapeutic drug for the treatment of leukemia and lymphoma.

References: ournilhac O, et al. Impact of frontline fludarabine and cyclophosphamide combined treatment on peripheral blood stem cell mobilization in B-cell chronic lymphocytic leukemia. Blood. 2004 Jan 1;103(1):363-5. Epub 2003 Sep 11.

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Molecular Weight (MW)285.23
Molecular FormulaC10H12FN5O4
CAS No.21679-14-1
Storage-20℃ for 3 years in powder formrr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 57 mg/mL (199.8 mM)rr
Water: <1 mg/mLrr
Ethanol: <1 mg/mL
Solubility In Vivo30% propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
SynonymsFaraA, Fludarabinum; HSDB 6964; F-ara-A, HSDB6964; NSC118218; HSDB-6964; NSC 118218; F-ara A, NSC-118218
ProtocolIn VivoFludarabine (0.8 mg/kg; i.p.; two cycles for 5 days every 2 weeks) in combination with Cyclophosphamide (400 mg/kg; i.p.; 2 weeks) decreases incidence of GVHD
Animal model
FormulationF-1 mice received 105 BCL-1 leukemia cells
Dosages0.8 mg/kg
AdministrationIntraperitoneal injection; two cycles for 5 days every 2 weeks
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.5059 mL17.5297 mL35.0594 mL70.1189 mL
5mM0.7012 mL3.5059 mL7.0119 mL14.0238 mL
10mM0.3506 mL1.7530 mL3.5059 mL7.0119 mL
20mM0.1753 mL0.8765 mL1.7530 mL3.5059 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.