Rasarfin is a novel dual Ras and ARF6 inhibitor, which blocks agonist-mediated internalization of AT1R and other GPCRs.

Methylophiopogonanone B is a novel and potent antioxidant ability.

MRTX0902 (MRTX-0902) is a novel, potent, selective, brain-penetrant, and orally bioavailable SOS1 binder that disrupts the SOS1:KRASG12C PPI (protein-protein interaction) with a binding Ki of 1.9 nM and IC50 of 29 nM in MKN1 cells.

MBQ-167 (MBQ167) is a dual inhibitor of Rac/Cdc42 (Ras-related C3 botulinum toxin substrate and cell division control protein 42 homolog) with anticancer activity.

ML098 (also known as CID-7345532) is a potent activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM.

4-(1,3-Benzothiazol-2-ylsulfanyl)-3-chloroaniline is a biochemical.

CID-44216842 is a novel and potent Cdc42-selective guanine nucleotide binding lead inhibitor.

Adagrasib (MRTX-849; Krazati) is a newly approved, selective, orally bioavailable and covalent / irreversible inhibitor of KRAS G12C with IC50s ranging between 10 and 973 nM in the 2D format and between 0.2 and 1042 nM in the 3D format.

RBC8 is a novel and potent inhibitor of Ral GTPase with IC50 of 3.5 μM in H2122 cells and 3.4 μM in H358 cells.

BI-3406 (BI3406; SOS1-IN-2) is a novel, orally bioactive, and selective inhibitor of Son of Sevenless 1 (SOS1) with anticancer activity.