ML-098
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $539 | Check With Us |
| 500mg | $799 | Check With Us |
| 1g | $1200 | Check With Us |
: Cat #: V4020 CAS #: 878978-76-8 Purity ≥ 98%
Description: ML098 (also known as CID-7345532) is a potent activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM.
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| Molecular Weight (MW) | 309.37 |
|---|---|
| Molecular Formula | C19H19NO3 |
| CAS No. | 878978-76-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 25 mg/mLr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | O=C(C1=CN(CCOC2=CC(C)=CC=C2C)C3=C1C=CC=C3)O |
| Synonyms | CID-7345532; CID 7345532; CID7345532; ML-098; ML 098; ML098 |
| Protocol | In Vitro | Probe compound mL098 (CID-7345532) functions by increasing the affinity of the GTPases for guanine nucleotides, leading to the hypothesis that these activators interact with GTPases bind to an allosteric binding site localized between switch regions I and II. ML-098 is an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM which shows selectivity against the related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively) |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.2324 mL | 16.1619 mL | 32.3238 mL | 64.6475 mL |
| 5mM | 0.6465 mL | 3.2324 mL | 6.4648 mL | 12.9295 mL |
| 10mM | 0.3232 mL | 1.6162 mL | 3.2324 mL | 6.4648 mL |
| 20mM | 0.1616 mL | 0.8081 mL | 1.6162 mL | 3.2324 mL |
The molarity calculator equation
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.