Adagrasib (MRTX849)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$1000	In Stock
1g	$1500	In Stock
5g	$4050	In Stock

: [email protected] [email protected]

Cat #: V34672 CAS #: 2326521-71-3 Purity ≥ 98%

Description: Adagrasib (MRTX-849; Krazati) is a newly approved, selective, orally bioavailable and covalent / irreversible inhibitor of KRAS G12C with IC50s ranging between 10 and 973 nM in the 2D format and between 0.2 and 1042 nM in the 3D format.

References: Christensen JG, et al. The KRASG12C Inhibitor, MRTX849, Provides Insight Toward Therapeutic Susceptibility of KRAS Mutant Cancers in Mouse Models and Patients. Cancer Discov. 2019 Oct 28. pii: CD-19-1167.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	604.12
Molecular Formula	C32H35ClFN7O2
CAS No.	2326521-71-3

Protocol	In Vitro	MRTX849 (0.1-10000 nM; 3-day/2D condition, 12-day/3D condition) has a significant inhibitory effect on the growth of the vast majority of KRAS G12C mutant cell lines, its IC50 It is 2~10 nM in 973D conditions and 3.0~2 nM in 1042D conditions
	In Vivo	MRTX849 (1-100 mg/kg； Oral gavage; once daily to day 16) Dose-dependent antitumor efficacy is shown within a well-tolerated dose range, with a maximum effective dose of MRTX849 between 30 and 100 mg/kg/day
	Animal model	MIA PaCa-2 model (6-8-week-old, female, athymic nude-Foxn1 nu mice)
	Dosages	1, 3, 10, 30 and 100 mg/kg
	Administration	Oral gavage; daily until Day 16

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.6553 mL	8.2765 mL	16.5530 mL	33.1060 mL
5mM	0.3311 mL	1.6553 mL	3.3106 mL	6.6212 mL
10mM	0.1655 mL	0.8277 mL	1.6553 mL	3.3106 mL
20mM	0.0828 mL	0.4138 mL	0.8277 mL	1.6553 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.