PD 123319 [PD-123319; PD123319; (S)-(+)-PD 123319] is a novel, potent, and selective AT2 (angiotensin II) receptor antagonist with anti-hypertensive effects.
Quinapril HCl (formerly CI-906, PD-109452-2; Acequin; Korec; Accupril; Accuprin; Accupril), the hydrochloride salt form of quinapril which is the prodrug of quinaprilat, is an angiotensin-converting enzyme/ACE inhibitor with anti-hypertensive effects. It is an approved antihypertensive drug that inhibits ACE with a Ki of 20 μM. Quinapril is a prodrug that has to to be converted […]
Candesartan (also known as CV-11974; Blopress, Atacand, Amias, Ratacand) is an approved antihypertensive drug acting as an AT II/angiotensin II receptor antagonist with IC50 of 0.26 nM.
Enalapril maleate (formerly MK-421; MK421; Glioten; Vasotec; Baripril; Renitec; Renitek), the maleate salt of enalapril, is a potent nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitor widely used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.
Ramipril (HOE-498; Altace; Carasel; Ramace; Zabien; Tritace; Ramace; Triatec; Tritace; Vesdil) is a potent angiotensin-converting enzyme (ACE) inhibitor with anti-hypertensive effects.
Losartan Potassium (formerly DuP-753; MK-954; DuP753; MK954; Cozaar; Lorzaar; Losaprex), the potassium salt of losartan, is an oral, selective, and non-peptide angiotensin II receptor antagonist approved as an antihypertensive drug.
Azilsartan Medoxomil (formerly also known as TAK-491), the ester prodrug of Azilsartan (TAK-536), is a potent and orally bioavailable angiotensin II type 1 (AT1) receptor antagonist, inhibits the RAAS, with an IC50 of 2.6 nM.
LCZ696 (LCZ-696; LCZ 696; Entresto; Sacubitril mixture with Valsartan), the combination of valsartan with sacubitril in 1:1 molar ratio, is an orally bioavailable and dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) approved in 2015 for the treatment of hypertension and heart failure.
Telmisartan (formerly BIBR-277; BIBR 277; BIBR277; Kinzalmono; Micardis) is a long lasting angiotensin II receptor antagonist (ARB) approved for use in the management of hypertension.
Candesartan Cilexetil (formerly TCV-116; CV11974; CV-11974; Atacand), an ester prodrug of Candesartan, is an antihypertensive drug acting as an AT II/angiotensin II receptor antagonist with anti-hypertensive effects.