Candesartan (CV 11974)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $249 | Check With Us |
| 1g | $400 | Check With Us |
| 5g | $1080 | Check With Us |
: Cat #: V1772 CAS #: 139481-59-7 Purity ≥ 98%
Description: Candesartan (also known as CV-11974; Blopress, Atacand, Amias, Ratacand) is an approved antihypertensive drug acting as an AT II/angiotensin II receptor antagonist with IC50 of 0.26 nM.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 440.45 |
|---|---|
| Molecular Formula | C24H20N6O3 |
| CAS No. | 139481-59-7 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 88 mg/mL (199.8 mM)rr |
| Water:<1 mg/mLrr | |
| Ethanol:<1 mg/mL | |
| Solubility In Vivo | 30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL |
| Synonyms | CV11974; CV-11974, CV 11974, Trade names: Blopress, Atacand, Amias, and Ratacand |
| Protocol | In Vivo | Candesartan (intraperitoneal injection; 1 mg/kg/day; Sustained 1, 3, or 28 dpi) has neuroprotective effects that reduce neuronal damage, reduce damage volume and microglia activation, protect CBF, and improve functional behavior in mouse models of TBI |
|---|---|---|
| Animal model | C57BL/6 mice (nine-week-old, male, 22–28 | |
| Dosages | 1 mg/kg | |
| Administration | i.p.; 1 mg/kg/day; continuously for 1, 3 or 28 dpi. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2704 mL | 11.3520 mL | 22.7041 mL | 45.4081 mL |
| 5mM | 0.4541 mL | 2.2704 mL | 4.5408 mL | 9.0816 mL |
| 10mM | 0.2270 mL | 1.1352 mL | 2.2704 mL | 4.5408 mL |
| 20mM | 0.1135 mL | 0.5676 mL | 1.1352 mL | 2.2704 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.