Telmisartan (BIBR 277)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $250 | In Stock |
| 10g | $750 | In Stock |
| 20g | $1125 | In Stock |
: Cat #: V1775 CAS #: 144701-48-4 Purity ≥ 98%
Description: Telmisartan (formerly BIBR-277; BIBR 277; BIBR277; Kinzalmono; Micardis) is a long lasting angiotensin II receptor antagonist (ARB) approved for use in the management of hypertension.
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| Molecular Weight (MW) | 514.62 |
|---|---|
| Molecular Formula | C33H30N4O2 |
| CAS No. | 144701-48-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 13 mg/mL (25.3 mM)r |
| Water:<1 mg/mLr | |
| Ethanol:<1 mg/mL | |
| Synonyms | Telmisartan; BIBR277; BIBR 277; BIBR-277; Kinzalmono; Micardis; |
| Protocol | In Vitro | In intact RVSMC cell and membrane formulations, Telmisartan is inhibited in a concentration-dependent manner125Binding of I-AngII to AT1 receptors, IC50 is 9.2 ± 0.8 nM. Under the same experimental conditions, angiotensin II was substituted125I-AngII，IC50 The value is 2.9 ± 0.5 nM. [3H]Specific binding of Telmisartan to SMC membranes to ICs replaced by unlabeled Telmisartan and cold AngII50 The values are 7.7 ± 1.8 nM and 32.7 ± 5.7 nM, respectively |
|---|---|---|
| In Vivo | In intact RVSMC cell and membrane formulations, Telmisartan is inhibited in a concentration-dependent manner125Binding of I-AngII to AT1 receptors, IC50 is 9.2 ± 0.8 nM. Under the same experimental conditions, angiotensin II was substituted125I-AngII，IC50 The value is 2.9 ± 0.5 nM. [3H]Specific binding of Telmisartan to SMC membranes to ICs replaced by unlabeled Telmisartan and cold AngII50 The values are 7.7 ± 1.8 nM and 32.7 ± 5.7 nM, respectively |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9432 mL | 9.7159 mL | 19.4318 mL | 38.8636 mL |
| 5mM | 0.3886 mL | 1.9432 mL | 3.8864 mL | 7.7727 mL |
| 10mM | 0.1943 mL | 0.9716 mL | 1.9432 mL | 3.8864 mL |
| 20mM | 0.0972 mL | 0.4858 mL | 0.9716 mL | 1.9432 mL |
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The dilution calculator equation
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
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mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.