ARV-771 (ARV771) is a novel and potent PROTAC-based degrader of bromodomain and extra-terminal (BET) proteins with the potential to be used in the treatment of cancers such as CRPC.

PROTAC B-Raf degrader 1 is a PROTAC degrader

E3 ligase Ligand-Linker Conjugates 35 Hydrochlridecomprises of an cIAP1 ligand for the E3 ubiquitin ligase and a PROTAC linker.

PROTAC ABL binding moiety 3 is a warhead targeting the BCR-ABL kinase for degradation via PROTAC technology.

ERD-308 (ERD308) is a highly potent PROTAC degrader of estrogen receptor (ER) with the potential for treating ER positive breast cancer treatment (DC50: 0.17 nM (ER in MCF-7 cells)).

PROTAC IAP binding moiety 2 is a warhead targeting IAP, used in PROTAC technology.

PROTAC IAP binding moiety 1 is a warhead targeting IAP, used in PROTAC technology.

E3 ligase Ligand-Linker Conjugates 33comprises of an cIAP1 ligand for the E3 ubiquitin ligase and a PROTAC linker.

TD-428 is a novel, potent and highly specific BRD4 targeting PROTAC degrader with a DC50 of 0.32 nM.

Homo-PROTAC cereblon degrader 1 (compound 15a) is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3.