ERD-308
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $3000 | To Be Confirmed |
| 200mg | $4500 | To Be Confirmed |
| 500mg | $7595 | To Be Confirmed |
: Cat #: V31331 CAS #: 2320561-35-9 Purity ≥ 99%
Description: ERD-308 (ERD308) is a highly potent PROTAC degrader of estrogen receptor (ER) with the potential for treating ER positive breast cancer treatment (DC50: 0.17 nM (ER in MCF-7 cells)).
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 1004.26 |
|---|---|
| Molecular Formula | C55H65N5O9S2 |
| CAS No. | 2320561-35-9 |
| SMILES Code | O=C([C@H]1N(C([C@@H](NC(COCCCCCN(CC)CCOC2=CC=C(C(C3=C(C4=CC=C(O)C=C4)SC5=CC(O)=CC=C53)=O)C=C2)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C |
| Synonyms | ERD-308; ERD 308; ERD308; |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 0.9958 mL | 4.9788 mL | 9.9576 mL | 19.9152 mL |
| 5mM | 0.1992 mL | 0.9958 mL | 1.9915 mL | 3.9830 mL |
| 10mM | 0.0996 mL | 0.4979 mL | 0.9958 mL | 1.9915 mL |
| 20mM | 0.0498 mL | 0.2489 mL | 0.4979 mL | 0.9958 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.