E3 ligase Ligand-Linker Conjugates 15comprises of a cereblon ligand for the E3 ubiquitin ligase and a PROTAC linker.
ZXH-3-26 is a novel, potent and selective degrader of BRD4 with a DC50/5h (half-maximal degradation after 5 hours of treatment) of ~ 5 nM.
THAL-SNS-032 is a novel, potent and selective CDK9 degrader baed on PROTAC technology to degrade CDK9.
AT6 is a novel, potent and highly selective PROTAC-based BRD degrader, it is analog of AT1.
dBET1 is a novel, potent, and competitive CRBN-based BET degrader (PROTAC) with an IC50 of 20 nM.
BSJ-03-123 is a novel, potent cyclin-dependent kinase 6 (CDK6)-selective small-molecule degrader (PROTAC: proteolysis targeting chimera).
dBET6 is a novel, highly potent, selective and cell-permeable chemical degrader of BET bromodomain proteins based on PROTAC technology with an IC50 of 14 nM.
PROTAC ERα Degrader-1 is a PROTAC degrader
Driselase, a mixture of cell wall degrading enzymes containing ellulase, hemicellulase, pectinase etc, is used for fungal protoplasting enzyme preparation.
E3 ligase Ligand 13 is a compound used in PROTAC technology to recruit E14 ligase.