THAL-SNS-032
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1850 | To Be Confirmed |
| 250mg | $2850 | To Be Confirmed |
| 500mg | $4275 | To Be Confirmed |
: Cat #: V3487 CAS #: 2139287-33-3 Purity ≥ 98%
Description: THAL-SNS-032 is a novel, potent and selective CDK9 degrader baed on PROTAC technology to degrade CDK9.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 869.02 |
|---|---|
| Molecular Formula | C40H52N8O10S2 |
| CAS No. | 2139287-33-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C(C1CCN(CC(NCCOCCOCCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)CC1)NC5=NC=C(SCC6=NC=C(C(C)(C)C)O6)S5 |
| Synonyms | THAL-SNS-032; THALSNS032; THAL SNS 032; THAL-SNS 032; THAL SNS-032; THAL-SNS032; THALSNS-032 |
| Protocol | In Vitro | THAL-SNS-032 inhibits proliferation of MOLT4 cells with an IC50 of 50 nM. THAL-SNS-032 diminishes elongating polymerase II. THAL-SNS-032 selectively induces degradation of CDK9. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.1507 mL | 5.7536 mL | 11.5072 mL | 23.0144 mL |
| 5mM | 0.2301 mL | 1.1507 mL | 2.3014 mL | 4.6029 mL |
| 10mM | 0.1151 mL | 0.5754 mL | 1.1507 mL | 2.3014 mL |
| 20mM | 0.0575 mL | 0.2877 mL | 0.5754 mL | 1.1507 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.