Pancreatic Polypeptide, human, is a C-terminally amidated 36-amino acid (AA) polypeptide that works as a neuropeptide Y (NPY) Y4/Y5 receptor agonist (activator).

Afamelanotide (Melanotan I; MT-I; CUV-1647; MBJ05; trade name Scenesse) is a synthetic peptide analog of α-melanocyte stimulating hormone (α-MSH), acting as a melanocortin receptor agonist and has been approved for use to prevent skin damage from the sun in people with erythropoietic protoporphyria in EU and USA. Skin becomes darker as a result (it produces […]

Pinocembrin-7-O-β-D-glucopyranoside (Pinocembrin 7-O-β-D-Glucoside) is a flavonoid that enhances lipid peroxidation.

Kuwanon H is a flavonoid compound in mulberry and is a non-peptide bombesin receptor blocker (antagonist). Kuwanon H can specifically inhibit the binding of intracellular gastrin-releasing peptide CRP to (GRP-preferring recepotr) receptors, with Ki of 290 nM.

4-Bromo A23187 is a halogenated analog of A-23187. A-2318 is a selective calcium ionophore. 4-Bromo A23187 is a calcium regulator that can cause apoptosis, like HL-60 cells.

Monochlorobimane (Chlorobimane) is a fluorescent dye reagent (λex=380 nm, λem=470 nm) used to measure glutathione (GSH) in cells.

ORM-10962 is a potent and selective sodium-calcium exchanger (NCX) inhibitor (antagonist) with IC50s of 67 nM and 55 nM for reverse and forward mode inhibition, respectively. ORM-10962 has antiarrhythmic effects.

Dehydronuciferine, extracted from the leaves of Nelumbo nucifera Gaertn, is an acetylcholinesterase (AChE) inhibitor (antagonist) with IC50 of 25 μg/mL.

Polyphyllin II is one of the most important saponins in Chonglou and has toxic effects on a variety of cancer/tumor cells. Polyphyllin II causes apoptosis through caspase activation and cell cycle arrest.

Garcinone C is a xanthone analogue, a natural compound found in Garcinia oblongifolia. It is used as an anti~inflammatory, astringent and granulation-promoting active molecule and may be utilized in certain cancers. cell toxicity/cytotoxicity. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while effectively inhibiting the expression levels of cyclin B1, cyclin D1, cyclin […]