ACT-660602 (ACT660602) is a novel antagonist of chemokine receptor (CXCR3) with the potential for autoimmune diseases. It inhibits CXCR3 with an IC50 value of 204 nM. ACT-660602 inhibits T-cell migration and shows efficacy in acute lung ingury model. It reduced recruitment of the CXCR3+ CD8+ T cell in the bronchoalveolar lavage compartment when administered orally […]

4-Methylumbelliferyl phosphate is a novel and potent fluorogenic substrate of phosphatases

Sculponeatin N, natural ent-kaurane diterpene derivative

(Rac)-RP-6306, Myt1 inhibitor

dTAG-47, heterobifunctional dTAG molecule, degrader of FKBP12F36V

JW-480, inhibitor of a serine hydrolase enzyme KIAA1363

Acotiamide (YM-443; Z-338) is a potent, orally bioactive and first-in-class gastroprokinetic agent for the treatment of functional dyspepsia. It is approved in Japan for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia.Acotiamide monohydrochloride trihydrate enhances acetylcholine released by enteric neurons through muscarinic receptor antagonism and acetylcholinesterase (AChE) inhibition, […]

ABAI-30, Anti-IBD agent, anti-inflammatory agent

Haloperidol decanoate is a novel and potent antipsychotic drug

KRAS G12D inhibitor 3 is novel potent and non-covalent KRAS G12D inhibitor (IC50