Capmatinib HCl, c-Met kinase inhibitor.

NS-3-008 is a novel and orally bioactive transcriptional inhibitor of G0/G1 switch 2 (G0s2). NS-3-008 can be used for chronic kidney disease. NS-3-008 inhibited the transcription of G0s2 with a half-maximal inhibitory concentration (IC50) of 2.25 μM. Moreover, treatment of wild-type 5/6Nx mice with NS-3-008 (5 mg/kg, P.O.) resulted in decreased levels of G0s2 and Ccl2 mRNA […]

SHMT-IN-2 is an inhibitor of human SHMT1/2 which is a serine hydroxymethyltransferase (SHMT). It has anticancer activity by inhibiting SHMT1/2 with IC50 values of 13 nM and 66 nM for SHMT1 and SHMT2, respectively.

(±)-Levomepromazine ((±)-Methotrimeprazine; dl-Methotrimeprazine) is the racemate of Levomepromazine, which is an orally bioactive antipsychotic agent.

GRK6-IN-1, inhibitor of G protein-coupled receptor kinase 6 (GRK6)

Palonosetron N-Oxide, impurity of Palonosetron which is anti-emetic agent used for preventing nausea and vomiting caused by cancer chemotherapy.

(E/Z)-Zotiraciclib citrate (TG02 citrate; SB1317 citrate is a novel and potent CDK2, JAK2, and FLT3 inhibitor with the potential for the treatment of cancer.

BAY-3827 (BAY3827) is a novel, potent and selective AMPK inhibitor with anticancer activity.

DDO-7263, Nrf2-ARE activator

Hyocholic Acid (3α,6α,7α-trihydroxy-5β-cholan-24-oic acid) is a biliary acid found mainly in pig as well as in human urine at low concentrations, in particular, in urine samples from patients with cholestasis. Hyocholic Acid can promote GLP-1 secretion via activating TGR5 and inhibiting FXR in enteroendocrine cells. It is known for its exceptional resistance to type 2 […]