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NS-3-008 HCl

This product is for research use only, not for human use. We do not sell to patients.

NS-3-008 HCl
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5mg$1003-6 Days
10mg$1503-6 Days
25mg$2503-6 Days
50mg$4503-6 Days
100mg$6503-6 Days
250mg$12503-6 Days
email: [email protected]        [email protected]

Cat #: V37656 CAS #: 1172854-54-4 Purity ≥ 99%

Description: NS-3-008 is a novel and orally bioactive transcriptional inhibitor of G0/G1 switch 2 (G0s2). NS-3-008 can be used for chronic kidney disease. NS-3-008 inhibited the transcription of G0s2 with a half-maximal inhibitory concentration (IC50) of 2.25 μM. Moreover, treatment of wild-type 5/6Nx mice with NS-3-008 (5 mg/kg, P.O.) resulted in decreased levels of G0s2 and Ccl2 mRNA in the kidneys.

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Molecular Weight (MW)269.817 
Molecular FormulaC14H24ClN3 
CAS No.1172854-54-4
SMILES CodeN=C(NCC1=CC=CC=C1)NCCCCCC.[H]Cl
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.