BMVC-8C3O is a novel ligand of DNA G-quadruplexe (G4) that can induce topological conversion of non-parallel to parallel forms in human telomeric DNA G4s.

MYLS22 (MYL-S22) is a novel and specific optic atrophy 1 (OPA1) inhibitor with anti-cancer and anti-angiogenesis activity.

Cefpodoxime (R-3763; U-76253A) is a broad spectrum antibacterial agent that acts by binding to penicillin binding proteins (PBPs), thus inhibiting peptidoglycan synthesis, leading to disruption of bacterial cell wall biosynthesis. Cefpodoxime is active against most Gram-positive and Gram-negative organisms. Cefpodoxime Proxetil has been widely used to treat acute otitis media, pharyngitis, sinusitis, and gonorrhea.

Compound 6q is a novel and potent steroidal anti-inflammatory agent that has the potential to be used in the treatment of IBD (inflammatory bowel diseases). Compound 6q effectively inhibited the production of nitric oxide (NO) in lipopolysaccharide (LPS) stimulated RAW 264.7 macrophages. It also inhibited the expression of inducible NO synthase (iNOS) and prostaglandin synthase-2 […]

(R)-Apremilast ((R)-CC-10004) is the R-isomer of Apremilast (also known as CC-10004), which is a thalidomide analog and is a novel and orally bioavailable small molecule inhibitor of the phosphodiesterase 4 (PDE4) with potential anti-inflammatory activity. It regulates inflammation through multiple cAMP downstream effectors. Apremilast inhibits PDE4 with an IC50 of 74 nM using 1 μM […]

β-Naphthol violet is an antiseptic and dye used for the chemical analysis to detect the ferric ion.

Benzimidazole is a heterocyclic compound commonly and widely used for the synthesis of many bioactive molecules with various biological activities such as anti-cancer, anti-viral, anti-bacterial, anti-fungal, anti-helmintic, anti-inflammatory, proton pump inhibitor and anti-coagulant property.

Capmatinib HCl, c-Met kinase inhibitor.

NS-3-008 is a novel and orally bioactive transcriptional inhibitor of G0/G1 switch 2 (G0s2). NS-3-008 can be used for chronic kidney disease. NS-3-008 inhibited the transcription of G0s2 with a half-maximal inhibitory concentration (IC50) of 2.25 μM. Moreover, treatment of wild-type 5/6Nx mice with NS-3-008 (5 mg/kg, P.O.) resulted in decreased levels of G0s2 and Ccl2 mRNA […]

SHMT-IN-2 is an inhibitor of human SHMT1/2 which is a serine hydroxymethyltransferase (SHMT). It has anticancer activity by inhibiting SHMT1/2 with IC50 values of 13 nM and 66 nM for SHMT1 and SHMT2, respectively.