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(R)-Apremilast ((R)-CC10004)

This product is for research use only, not for human use. We do not sell to patients.

(R)-Apremilast ((R)-CC10004)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5mg$2253-6 Days
10mg$4003-6 Days
25mg$7003-6 Days
50mg$12503-6 Days
email: [email protected]        [email protected]

Cat #: V37604 CAS #: 608141-44-2 Purity ≥ 99%

Description: (R)-Apremilast ((R)-CC-10004) is the R-isomer of Apremilast (also known as CC-10004), which is a thalidomide analog and is a novel and orally bioavailable small molecule inhibitor of the phosphodiesterase 4 (PDE4) with potential anti-inflammatory activity. It regulates inflammation through multiple cAMP downstream effectors. Apremilast inhibits PDE4 with an IC50 of 74 nM using 1 μM cAMP as substrate. Apremilast inhibits spontaneous production of TNF-alpha from human rheumatoid synovial cells. Apremilast was approved by the FDA in 2014 for treatment of adults with active psoriatic arthritis. It is also being tested for its efficacy in treating other chronic inflammatory diseases such as ankylosing spondylitis, Behcet's disease, and rheumatoid arthritis.

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Molecular Weight (MW)460.50 
Molecular FormulaC₂₂H₂₄N₂O₇S 
CAS No.608141-44-2
Synonyms <span id="xn_c_prodv_37_conT1_t">CC-10004; CC10004; CC 10004
The molarity calculator equation
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.