Avibactam Impurity 6 is an impurity of Avibactam (NXL-104; NXL104; Avycaz), which is a non-β lactam β-lactamase inhibitor that inactivates β-lactamases and has been approved for use in combination with ceftazidime (trade name Avycaz) for treating bacterial infections.

Hexachlorophene (Hexachlorofen) is a chlorinated bisphenol antiseptic agent acting as a KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM. It is also an inhibitor of Wnt/beta-catenin signaling.

Diisopropyl tartrate is a reagent for kinetic resolution of racemic allylic alcohols and α-furfuryl amides by enantioselective epoxidation.

Aripiprazole lauroxil (RDC3317; RDC-3317; ALKS 9070; ALKS-9072; Abilify; Aristada) is a long-acting injectable atypical antipsychotic approved in 2015 by FDA mainly for the treatment of schizophrenia and bipolar disorder. It can also be used as an add-on treatment in major depressive disorder, tic disorders and irritability associated with autism. Aripiprazole lauroxil is an N-acyloxymethyl prodrug […]

CRT0036521 is a potent and selective inhibitor of AKR1C3.

SCH-79797 (SCH79797) is a novel, potent and selective PAR1 (protease activated receptor 1) antagonist with an IC50 of 70 nM and a Ki of 35 nM. SCH-79797 limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 dihydrochloride inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. SCH 79797 protects against ischemia/reperfusion-induced arrhythmias in the rat […]

BI6015 is a novel and potent antagonist of Hepatocyte nuclear factor 4α (HNF4α)

Cefpodoxime Proxetil (Doxef; CS-807; U-76252;) is a broad spectrum antibacterial agent that acts by binding to penicillin binding proteins (PBPs), thus inhibiting peptidoglycan synthesis, leading to disruption of bacterial cell wall biosynthesis. It is an ester prodrug of the active free acid metabolite Cefpodoxime, and is active against most Gram-positive and Gram-negative organisms. Cefpodoxime Proxetil […]

GLPG-0259 (GLPG0259) is a novel, potent and selective small-molecule inhibitor of mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5) with the potential for the treatment of rheumatoid arthritis. MAPKAPK5 is a kinase that plays an important role in inflammatory pathways. It is a key regulator of cytokine production, and is therefore a potential target for treatment […]

Chlorothiazide is a potent thiazide diuretic with antihypertensive effects. It is used within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure.