NXP-800 (also known as DEL22379; DEL-22379) is a potent ERK dimerization inhibitor and heat shock factor 1 (HSF1) inhibitor with anticancer effects.
TRC051384 is a novel compound which can potently induce HSPA1A/B (heat shock protein) expression and subsequent Hsp70 production via heat shock factor-1 (HSF1) activation.
VER-49009 (CCT0129397; VER 49009; CCT-0129397; VER49009), a pyrazole-based compound, is a novel, potent and selective inhibitor of HSP90 (Heat Shock Protein 90) with potential antitumor activity.
VER-155008 (VER 155008; VER155008) is an HSP70 (heat shock protein 70) inhibitor with anti-AD (alzheimer’s disease) effects.
PF-04929113 (SNX-5422; PF04929113; PF-4929113) is a potent and selective inhibitor of heat shock protein 90 (HSP90) with potential antineoplastic activity.
Alvespimycin is a heat shock protein 90 (Hsp90) inhibitor and promising therapeutic agent for cancer.
MB-10, also known as MitoBloCK-10, is a novel, potent and first-in-class small molecule modulator that can attenuate the activity of protein-associated motor (PAM) complex.
HM03 (HM-03) is a novel, potent and selective HSPA5 (also known as Heat shock 70kDa protein 5, Bip, Grp78) inhibitor with anticancer activity.
YUM70 (YUM-70) is a novel and potent GRP78 (glucose-regulated protein 78) inhibitor (IC50=1.5 μM) with anticancer activity.
DTHIB is a potent,direct and selective heat shock factor 1 (HSF1) inhibitor ( Kd = 160 nM).