Cimetidine (Tagamet; Cimetag; SKF-92334; Eureceptor; Ulcedine), an approved drug used in the treatment of heartburn and peptic ulcers, is a potent histamine congener that competitively inhibits the binding of histamine to histamine H2 receptors.

SUN 1334H is a novel, potent, orally bioactive, and highly selective H1 receptor antagonist with Ki of 9.7 nM.

Diphenhydramine HCl is a potent and first-generation histamine H1 receptor antagonist and an antiemetic that is used in various allergic conditions such as rhinitis, urticaria and conjunctivitis.

Fexofenadine (MDL-16455A; MDL16455A; Allegra; Terfenidine carboxylate; Telfast) is a histamine H1 receptor antagonist (antihistamine agent) approved for the treatment of allergy symptoms such as hay fever, nasal congestion, and urticaria.

Brompheniramine (Bromfed, Dimetapp, Bromfenex, Dimetane, BPN, Lodrane), the maleate salt of Brompheniramine which is an OTC drug for cold and allergic rhinitis, is a first-generation antagonist of the histamine H1 receptors.

Osthol (Osthol; Ostol; NSC 31868) is an O-methylated coumarin analog and a natural product which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens.

Cyclizine 2HCl (Marezine; Ciclizina; Nautazine; Valoid; Neo-devomit), the dihydrochloride salt of cyclizine, is a potent and 1st generation histamine H1 receptor antagonist of the piperazine class with anticholinergic and antiemetic properties.

Bavisant (also known as JNJ-31001074) is a novel, highly selective, orally bioactive antagonist of the human H3 receptor with a novel mechanism of action which involves wakefulness and cognition.

Bepotastine (also known as TAU 284; Bepreve) is a second generation, non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7.

Rupatadine Fumarate (UR-12592; UR12592; Pafinur; Rupax; Rupafin; Alergoliber; Rinialer; Ralif), the fumarate salt of Rupatadine, is a potent inhibitor of PAFR and antagonist of histamine (H1) receptor used to treat allergies.