Cyclizine 2HCl

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
1g	$290	Check With Us
2g	$520	Check With Us
5g	$780	Check With Us

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Cat #: V1244 CAS #: 5897-18-7 Purity ≥ 98%

Description: Cyclizine 2HCl (Marezine; Ciclizina; Nautazine; Valoid; Neo-devomit), the dihydrochloride salt of cyclizine, is a potent and 1st generation histamine H1 receptor antagonist of the piperazine class with anticholinergic and antiemetic properties.

References: Leza JC, et, al. Effects of antihistaminics on locomotor activity in mice. Comparison with opiate and amphetamine-induced hyperactivity. Gen Pharmacol. 1991;22(2):293-6.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	339.3
Molecular Formula	C18H22N2.2HCl
CAS No.	5897-18-7
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 7 mg/mL (20.6 mM)r
	Water: 68 mg/mL (200.41 mM)r
	Ethanol: <1 mg/mL
Synonyms	Cyclizine 2HCl; Marezine; Ciclizina; Nautazine; Valoid; Neo-devomit

Protocol	In Vivo	Cyclizine (1, 10 mg/kg) dihydrochloride enhances locomotor activity of mice in a dose-dependent manner
	Animal model	Naive male CDI mice (Charles River) weighing 25-30 g
	Dosages	1, 10 mg/kg
	Administration	s.c.; locomotor activity (crossings) measured every 15 min for 2 hr

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.9472 mL	14.7362 mL	29.4724 mL	58.9449 mL
5mM	0.5894 mL	2.9472 mL	5.8945 mL	11.7890 mL
10mM	0.2947 mL	1.4736 mL	2.9472 mL	5.8945 mL
20mM	0.1474 mL	0.7368 mL	1.4736 mL	2.9472 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.