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Cimetidine

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Cimetidine
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50g$350Check With Us
100g$550Check With Us
200mg$825Check With Us
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Cat #: V1220 CAS #: 51481-61-9 Purity ≥ 98%

Description: Cimetidine (Tagamet; Cimetag; SKF-92334; Eureceptor; Ulcedine), an approved drug used in the treatment of heartburn and peptic ulcers, is a potent histamine congener that competitively inhibits the binding of histamine to histamine H2 receptors.

References: Zheng, Y., et al., Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells. Mol Immunol, 2013. 54(1): p. 74-83.

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Molecular Weight (MW)252.34
Molecular FormulaC10H16N6S
CAS No.51481-61-9
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 51 mg/mL (202.1 mM)r
Water: <1 mg/mLr
Ethanol: 3 mg/mL (11.9 mM)
Solubility In VivoChemical Name: 1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine InChi Key: AQIXAKUUQRKLND-UHFFFAOYSA-N InChi Code: InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14) SMILES Code: CC1=C(N=CN1)CSCCNC(=NC)NC#N
SynonymsSKF 92334; SKF92334; Cimetidine; Tagamet; Cimetag; SKF-92334; Eureceptor; Ulcedine
ProtocolIn VitroCimetidine showed no effect on proliferation, survival, migration and invasion of 3LL cells. Cimetidine reversed MDSC-mediated T-cell suppression, and improved IFN-γ production
In VivoCimetidine (SKF-92334) reduceS CD11b(+)Gr-1(+) myeloid derived-suppressive cell (MDSC) accumulation in spleen, blood and tumor tissue of tumor-bearing mice
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.9629 mL19.8145 mL39.6291 mL79.2581 mL
5mM0.7926 mL3.9629 mL7.9258 mL15.8516 mL
10mM0.3963 mL1.9815 mL3.9629 mL7.9258 mL
20mM0.1981 mL0.9907 mL1.9815 mL3.9629 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.